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凡默谷技术部选取和汇总了2015-2020年制剂体外崩解与溶出模拟软件DDDPlus发表的应用文章，并将标题翻译成中文。

希望对您的业务或专业学习有所帮助，内容如下：

1. 采用基于生理的吸收模型，探讨食物和胃液pH值变化对恩曲替尼Entrectinib药代动力学的影响

Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib.

Parrott N, Stillhart C, Lindenberg M, Wagner B, Kowalski K, Guerini E, Djebli N, Meneses-Lorente G.AAPS J(2020) 22:78.IF= 3.737

2. 使用基于生理的生物药剂学模型（PBBM）预测速释制剂空腹和餐后的生物等效性

Prediction of fasted and fed bioequivalence for immediate release drug products using physiologically based biopharmaceutics modeling (PBBM).

Jereb R, Kristl A, Mitra A.Eur J Pharm Sci.Volume 155, 1 December 2020, 105554.IF= 3.616

3. 制剂处方开发早期的无定型固体分散剂：使用DDDPlus预测辅料对溶出曲线的影响

Amorphous Solid Dispersions in Early Stage of Formulation Development: Predicting Excipient Influence on Dissolution Profiles Using DDDPlus.

Njoku JO, Mukherjee D, Webster GK, Löbenberg R.Dissolut Technol.MAY 2020.IF= 0.674

4. 药物制剂早期开发的计算机预测工具：所需的数据和软件的功能

In silico Tools at Early Stage of Pharmaceutical Development: Data Needs and Software Capabilities.

Njoku JO, Amaral Silva D, Mukherjee D, Webster GK, Löbenberg R.AAPS PharmSciTech.(2019) 20: 243.IF=2.401

5. 采用生理药代动力学PBPK模型，评估影响美托洛尔缓释药品生物等效性的制剂因素

Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended-Release Products.

Sumit Basu, Haitao Yang, Lanyan Fang, Mario Gonzalez‐Sales, Liang Zhao, Mirjam N. Trame, Lawrence Lesko, Stephan Schmid.J Clin Pharmacol.Volume59, Issue9. September 2019 Pages 1252-1263.IF=2.425

6. 评估制剂处方变异对临床的影响：以美托洛尔缓释制剂作为研究案例

Evaluating the Clinical Impact of Formulation Variability: A Metoprolol Extended‐Release Case Study.

Kim S, Sharma VD, Lingineni K, Farhan N, Fang L, Zhao L, Brown J, Cristofoletti R, Vozmediano V, Ait-Oudhia S, Lesko LJ, Trame MN, Schmidt S.J Clin Pharmacol.May 14, 2019.IF=2.425

7. 建立体外-体内相关的溶出和转化建模策略-某研讨会总结汇总

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link-a Workshop Summary Report.

Heimbach T, Suarez-Sharp S, Kakhi M, Holmstock N, Olivares-Morales A, Pepin X, Sjögren E, Tsakalozou E, Seo P, Li M, Zhang X, Lin HP, Mitra A, Morris D, Patel N, Kesisoglou F.AAPS J.Feb 11, 2019.IF=3.737

8. 用于体外-体内外推转化IVIVE的生理药代动力学PBPK建模：强调溶出数据的使用

Physiologically Based Pharmacokinetic (PBPK) Modelling for In Vitro-In Vivo Extrapolation: Emphasis on the Use of Dissolution Data

Vivek M. Ghate, Pinal Chaudhari, and Shaila A. Lewis.Dissolut Technol.August 2019.IF= 0.674

9. 药品开发中的溶出测试：研讨会总结报告

Dissolution Testing in Drug Product Development: Workshop Summary Report

Andreas Abend, David Curran, Jesse Kuiper, Xujin Lu, Hanlin Li, Andre Hermans, Pramod Kotwal, Dorys A Diaz, Michael J Cohen, Limin Zhang, Erika Stippler, German Drazer, Yiqing Lin, Kimberly Raines, Lawrence Yu, Carrie A Coutant, Haiyan Grady, Johannes Krämer, Sarah Pope-Miksinski, Sandra Suarez-Sharp.AAPS J.2019 Jan 28;21(2):21.IF=3.737

10. 通过计算机模拟溶出曲线，开发多沙唑嗪缓释片

In Silico Simulation of Dissolution Profiles for Development of Extended-Release Doxazosin Tablets.

Duque MD, Issa MG, Silva DA, Barbosa EJ, Löbenberg R, Ferraz HG.Dissolut Technol.NOVEMBER 2018. IF= 0.674

11. 用于评估膳食对缓释制剂释放的影响的生理学考虑和体外策略

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations.

Koziolek M, Kostewicz ES, Vertzoni M.AAPS PharmSciTech.Aug 28, 2018.IF=2.401

12. 采用体外方法评估空腹状态下，药物在小肠中的沉淀-PEARRL综述

In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review.

O’Dwyer PJ, Litou C, Box KJ, Dressman JB, Kostewicz ES, Kuentz M, Reppas C.J Pharm Pharmacol.2018 Jun 28.IF=2.571

13. 溶出过程中，十二烷基硫酸钠载药不完全和分散颗粒剂的扩散层内的空腹状态下的模拟肠液胶束

Incomplete Loading of Sodium Lauryl Sulfate and Fasted State Simulated Intestinal Fluid Micelles Within the Diffusion Layers of Dispersed Drug Particles During Dissolution

Kendra Galipeau, Michael Socki, Adam Socia, Paul A. Harmon.Journal of Pharmaceutical Sciences.107 (2018) 156-169.IF=2.997

14. 针对BCS溶解度分类的高溶解度和难溶性药物的固有溶出度模拟

Intrinsic dissolution simulation of highly and poorly soluble drugs for BCS solubility classification.

Duque MD, Issa MG, Silva DA, Kakuda BAS, Rodrigues LNC, Löbenberg R, Ferraz HG.Dissolution Technologies.2017 Nov.IF=0.674

15. 使用体外和计算机模拟模型证明超出FDA标准范围的崩解测试方法的可行性

Justification of disintegration testing beyond current FDA criteria using in vitro and in silico models

Lukas Uebbing, Lukas Klumpp, Gregory K Webster, Raimar Löbenberg.Drug Design, Development and Therapy.April 2017.IF=3.216

16. 采用DDDPlus™模拟药物的体外溶出行为

Simulation of In Vitro Dissolution Behavior Using DDDPlus™

Almukainzi M, Okumu A, Wei H, Löbenberg R.AAPS PharmSciTech.Feb, 2015.IF=2.401

17. 体外-体内相关性IVIVC：通用概念，方法，在法规监管中的应用

In vitro–in vivo correlations: general concepts, methodologies and regulatory applications [J].

González-García I, Mangas-Sanjuán V, Merino-Sanjuán M, et al.Drug development and industrial pharmacy, 2015, 41(12): 1935-1947.IF=2.365

18. 生物相关性溶出度方法研究进展

缪慧，阮昊，陈悦，洪利娅.《中国现代应用药学》. 2018,35(01).综合影响因子：1.2

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